Diseases, Conditions, Syndromes

A new look inside Ebola's 'viral factories'

New research in the journal Nature Communications gives scientists an important window into how Ebola virus replicates inside host cells. The study, led by scientists at La Jolla Institute for Immunology (LJI), reveals the ...

Diseases, Conditions, Syndromes

Tanzania says five dead in Marburg virus outbreak

A mysterious disease that killed five people in Tanzania has been identified as Marburg hemorrhagic fever, a cousin of Ebola, the health ministry said on Tuesday.

Diseases, Conditions, Syndromes

WHO to hold emergency meeting on E.Guinea Marburg outbreak

The UN health agency said it would hold an emergency meeting Tuesday after at least nine people in Equatorial Guinea died from Marburg haemorrhagic fever, a cousin of the Ebola virus.

Diseases, Conditions, Syndromes

Marburg virus vaccine shows promising results in first-in-human study

A newly published paper in The Lancet shows that an experimental vaccine against Marburg virus (MARV) was safe and induced an immune response in a small, first-in-human clinical trial. The vaccine, developed by researchers ...

Diseases, Conditions, Syndromes

WHO identifying potential pandemic pathogens

The World Health Organization said on Monday it was thrashing out a new list of priority pathogens that risk sparking pandemics or outbreaks and should be kept under close observation.

Diseases, Conditions, Syndromes

'Death every day': Fear and fortitude in Uganda's Ebola epicentre

As Ugandan farmer Bonaventura Senyonga prepares to bury his grandson, age-old traditions are forgotten and fear hangs in the air while a government medical team prepares the body for the funeral—the latest victim of Ebola ...

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Ebola

Ivory Coast ebolavirus Reston ebolavirus Sudan ebolavirus

Ebola is the common term for a group of viruses belonging to genus Ebolavirus (EBOV), which is a part of the family Filoviridae, and for the disease that they cause, Ebola hemorrhagic fever. The virus is named after the Ebola River, where the first recognized outbreak of Ebola hemorrhagic fever occurred. The viruses are characterized by long filaments, and have a shape similar to that of the Marburg virus, also in the family Filoviridae, and possessing similar disease symptoms.

There are a number of species within the ebolavirus genus, which in turn have a number of specific strains or serotypes. The Zaïre virus is the type species, which is also the first discovered and the most lethal. Ebola is transmitted primarily through bodily fluids and to a limited extent through skin and mucous membrane contact. The virus interferes with the endothelial cells lining the interior surface of blood vessels and platelet cells. As the blood vessel walls become damaged and the platelets are unable to coagulate, patients succumb to hypovolemic shock.

Ebola first emerged in 1976 in Zaire. It remained largely obscure until 1989 with a widely publicized outbreak in Reston, Virginia.

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