Medical research

Development and effectiveness of pseudotyped SARS-CoV-2 system

Coronavirus disease 2019 (COVID-19) has become a global pandemic. Currently, SARS-CoV-2 live virus-associated experiments need to be handled in biosafety level 3 (BSL-3) facilities. Previously, researchers had successfully ...

Diseases, Conditions, Syndromes

Ebola vaccine to begin human trials

The University of Oxford have begun recruiting for a Phase I trial to test an Ebola vaccine in human volunteers—with the first vaccinations having already taken place.

Diseases, Conditions, Syndromes

COVID-19 compared with other deadly viruses

The global death toll from COVID-19, which is set to pass five million, is already far worse than most other viral epidemics of the 20th and 21st centuries.

Diseases, Conditions, Syndromes

'No evidence' woman in Ivory Coast had Ebola: WHO

There is "no evidence" that a Guinean woman who tested positive for Ebola after arriving in neighbouring Ivory Coast had the disease, the WHO said on Tuesday citing a new analysis from a lab in France.

Diseases, Conditions, Syndromes

WHO says 49 Ebola contact cases identified in I. Coast

Forty-nine individuals have been identified who were in contact with a young Guinean woman who tested positive for the Ebola virus in Ivory Coast's biggest city Abidjan, the UN health agency said Thursday.

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Ivory Coast ebolavirus Reston ebolavirus Sudan ebolavirus

Ebola is the common term for a group of viruses belonging to genus Ebolavirus (EBOV), which is a part of the family Filoviridae, and for the disease that they cause, Ebola hemorrhagic fever. The virus is named after the Ebola River, where the first recognized outbreak of Ebola hemorrhagic fever occurred. The viruses are characterized by long filaments, and have a shape similar to that of the Marburg virus, also in the family Filoviridae, and possessing similar disease symptoms.

There are a number of species within the ebolavirus genus, which in turn have a number of specific strains or serotypes. The Zaïre virus is the type species, which is also the first discovered and the most lethal. Ebola is transmitted primarily through bodily fluids and to a limited extent through skin and mucous membrane contact. The virus interferes with the endothelial cells lining the interior surface of blood vessels and platelet cells. As the blood vessel walls become damaged and the platelets are unable to coagulate, patients succumb to hypovolemic shock.

Ebola first emerged in 1976 in Zaire. It remained largely obscure until 1989 with a widely publicized outbreak in Reston, Virginia.

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