Genetics

An unprecedented view of gene regulation

Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell. Those regulatory elements can be located near a target gene or up to 2 million base pairs away from ...

Medications

Novel drug makes mice skinny even on sugary, fatty diet

Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have developed a small-molecule drug that prevents weight gain and adverse liver changes in mice fed a high-sugar, high-fat ...

Oncology & Cancer

How genome doubling helps cancer develop

A single cell contains 2-3 meters of DNA, meaning that the only way to store it is to package it into tight coils. The solution is chromatin: a complex of DNA wrapped around proteins called histones. In the 3D space, this ...

Alzheimer's disease & dementia

Inflammatory trigger a new clue in Alzheimer's

Scientists from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) today reported that an inflammatory trigger like one present during viral infections is elevated in Alzheimer's disease ...

Genetics

Diabetes-causing gene can be regulated like a rheostat

Researchers at the Centre for Genomic Regulation (CRG) and Imperial College London have found a switch that regulates the activity of a gene that causes diabetes. The findings, published in Nature Cell Biology, highlight ...

Oncology & Cancer

Hallmark cancer gene regulates RNA 'dark matter'

A key genetic mutation that occurs early on in cancer alters RNA "dark matter" and causes the release of previously unknown RNA biomarkers for cancer early detection, a new study by UC Santa Cruz researchers published in ...

Oncology & Cancer

Study shows new strategy to boost immune system to fight melanoma

A new study led by Yale Cancer Center researchers shows that the enzyme KDM5B suppresses anti-melanoma immunity. These findings could help develop a new treatment strategy to benefit patients with melanoma and other cancers, ...

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