Diseases, Conditions, Syndromes

Renal-replacement timing has no effect in kidney injury, sepsis

(HealthDay)—For patients with early-stage septic shock and severe acute kidney injury, 90-day mortality does not differ for patients randomly assigned to an early strategy for initiation of renal-replacement therapy versus ...

Diseases, Conditions, Syndromes

Unique mechanism of action inhibiting paracellular phosphate absorption

Ardelyx, Inc. today announced that the novel mechanism of action for tenapanor for the treatment of hyperphosphatemia, or elevated serum phosphorus, has been published in the peer-reviewed journal Science Translational Medicine. ...

Genetics

Hybrid protein deregulates complement in dense deposit disease

Dense deposit disease is a rare congenital disorder that is associated with complement dysfunction and often results in end stage renal disease within 10 years of the initial diagnosis. A small percentage of dense deposit ...