Medical research

The biomechanics of vascular aging

Cardiovascular diseases (CVD) lead to atherosclerosis and heart failure and are prevalent age-related illnesses in humans. In a new study, published in the renowned journal JCI, scientists from Roland Foisner's group at the ...

Cardiology

Stretch, inflammation and hypertension

Monocytes are known to play an important role in hypertension, although the exact mechanism remains unclear. It is hypothesized that a potential source of monocyte activation originates from its interaction with the vascular ...

Medical research

Epigenetic program leading to vessel differentiation

Clarification of how human blood vessels are constructed is desperately needed to advance regenerative medicine. A collaborative research group from Kumamoto University, Kyoto University, and the University of Tokyo in Japan ...

Immunology

No platelets, no immune response

When a virus attacks our organism, an inflammation appears on the affected area which triggers off the process of immune defence within our body. White blood cells (such as neutrophils and inflammatory monocytes) move quickly ...

Medical research

Blood vessels can actually get better with age

Although the causes of many age-related diseases remain unknown, oxidative stress is thought to be the main culprit. Oxidative stress has been linked to cardiovascular and neurodegenerative diseases including diabetes, hypertension ...

Medical research

mTORC pathway involved in antiphospholipid sx vasculopathy

(HealthDay)—The mammalian target of rapamycin complex (mTORC) pathway seems to be involved in antiphospholipid syndrome-associated vascular lesions, according to a study published in the July 24 issue of the New England ...

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Endothelium

The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. These cells are called endothelial cells. Endothelial cells line the entire circulatory system, from the heart to the smallest capillary. These cells reduce turbulence of the flow of blood, allowing the fluid to be pumped farther.

Endothelial tissue is an epithelial tissue.

The endothelium normally provides a non-thrombogenic surface because it contains heparan sulfate which acts as a cofactor for activating antithrombin III, a protease that inactivates several factors in the coagulation cascade.

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