Arthritis & Rheumatism

Researcher evaluates estrogen as therapy for knee osteoarthritis

More than 30 million Americans suffer from osteoarthritis of the knee, according to the Centers for Disease Control and Prevention. The degenerative joint disease, often caused by wear and tear, is a leading cause of disability ...

Cancer

Rare variants associated with interval breast cancers

(HealthDay)—Though common breast cancer variants indicate increased breast cancer risk, certain rare variants are associated with an increased risk for interval breast cancers and death, according to a study published in ...

Medical research

Hidden estrogen receptors in the breast epithelium

Estrogens are hormones that play central roles in the development and the physiology of the breast, but also are involved in breast cancer. Like all hormones, estrogens exert their biological effects by binding to dedicated ...

Medical research

Age-related increase in estrogen may cause common men's hernia

An age-related increase in estrogen may be the culprit behind inguinal hernias, a condition common among elderly men that often requires corrective surgery, according to a Northwestern Medicine study was published Oct. 15 ...

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Estrogen

Estrogens (U.S., otherwise oestrogens or œstrogens) are a group of steroid compounds, named for their importance in the estrous cycle, and functioning as the primary female sex hormone, their name comes from estrus (period of fertility for female mammals) + gen = to generate.

Estrogens are used as part of some oral contraceptives, in estrogen replacement therapy for postmenopausal women, and in hormone replacement therapy for transwomen.

Like all steroid hormones, estrogens readily diffuse across the cell membrane. Once inside the cell, they bind to and activate estrogen receptors which in turn up-regulate the expression of many genes. Additionally, estrogens have been shown to activate a G protein-coupled receptor, GPR30.

This text uses material from Wikipedia, licensed under CC BY-SA