Studies of autoimmune and inflammatory diseases have identified hundreds of genetic regions thought to be associated with these conditions. At the same time, studies of expression quantitative trait loci (eQTLs) have revealed ...
Mar 15, 2017
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How is drug resistance of cancer cells affected by ABC-transporters? A new research paper, published in the open access journal BioDiscovery, looks at the complex relationship between the second generation of tyrosine kinase ...
Mar 8, 2017
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By comparing two strains of mice—one that becomes obese and diabetic on a high-fat diet and another resistant to a high-fat regimen—researchers from the Perelman School of Medicine at the University of Pennsylvania identified ...
Mar 8, 2017
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Scientists from the Engelhardt Institute of Molecular Biology and MIPT have studied the effects of Siberian fir terpenoids on senescent and human cancer cell lines at the genetic level. Research into terpenoids, including ...
Feb 28, 2017
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Obesity often leads to insulin resistance, a hallmark of type 2 diabetes. The anti-diabetic drug rosiglitazone counters insulin resistance in diabetic patients by targeting PPARγ, a nuclear receptor that senses hormones ...
Feb 27, 2017
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A handful of FDA-approved drugs exist for treating individuals with alcohol use disorder but they have been largely ineffective at reducing the high rates of relapse. As such, there remains a critical need to identify and ...
Jan 30, 2017
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Researchers at Bellvitge Biomedical Research Institute (IDIBELL), in collaboration with King's College London, have unveiled the role of NADPH oxidase NOX4 as an inhibitor of the epithelial-amoeboid transition, a process ...
Dec 20, 2016
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Japanese researchers have found that genes respond differently to the amount and rate of secretions of insulin, a hormone whose malfunction can lead to obesity and diabetes. Some genes express themselves quickly when stimulated ...
Nov 22, 2016
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(HealthDay)—Interleukin (IL)-32 has inflammatory and remodeling properties in human obesity, according to a study published online Sept. 14 in Diabetes.
Sep 20, 2016
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(HealthDay)—Alitretinoin treatment aids in normalizing expression of barrier genes and proteins in patients with chronic hand eczema (CHE), according to a study published online Aug. 2 in the British Journal of Dermatology.
Aug 12, 2016
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