Brain diseases associated with the misformed protein tau, including Alzheimer's disease and frontotemporal lobar degeneration with tau pathologies, are characterized by neurofibrillary tangles (NFTs) comprised of pathological ...
Jan 15, 2013
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In November, researchers reported the drug lecanemab slowed the progression of Alzheimer's disease. The effect was modest, but it has generated tremendous excitement because it was the first time a drug had been shown to ...
Dec 27, 2022
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A test of protein in the blood is receiving further support as a biomarker for patients diagnosed with frontotemporal dementia (FTD), a group of brain disorders with few treatment options. These disorders are characterized ...
Apr 19, 2022
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Nearly all major neurodegenerative diseases—from Alzheimer's to Parkinson's—are defined and diagnosed by the presence of one of four proteins that have gone rogue: tau, amyloid-beta (Aβ), alpha-synuclein (α-syn), or ...
Jul 5, 2018
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Two new studies published in the August issue of The Journal of Nuclear Medicine (JNM) provide insight into the potential of positron emission tomography (PET) to differentiate between types of dementia and to identify pharmaceuticals ...
Aug 1, 2011
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Experts at Indiana University School of Medicine have helped identify that a common protein found in neurodegenerative diseases forms amyloid filaments in an age-dependent manner without a connection to disease.
Mar 28, 2022
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Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset dementia, and can lead to personality changes, impaired speaking and motor dysfunction. While most cases occur sporadically, several ...
Feb 26, 2018
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Led by professor Ludo Van Den Bosch (VIB-KU Leuven), scientists from Belgium, the UK and the US have identified new processes that form protein "clumps" that are characteristic of amyotrophic lateral sclerosis (ALS) and frontotemporal ...
Mar 17, 2017
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Although the technology has existed for just a few years, scientists increasingly use "disease in a dish" models to study genetic, molecular and cellular defects. But a team of doctors and scientists led by researchers at ...
Oct 25, 2013
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Researchers in the Perelman School of Medicine at the University of Pennsylvania found that, across a variety of neurodegenerative diseases, cerebrovascular disease affecting circulation of blood in the brain was significantly ...
Jul 9, 2013
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