To find new treatment approaches for childhood cancer, scientists at St. Jude Children's Research Hospital are digging deep into disease biology to target a process long considered "undruggable." The approach revealed a new ...
Jul 13, 2022
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About one in five or six cases of adult leukaemia in Western populations relates to so-called chronic myeloid leukaemia, or CML. Treatment of CML usually relies on inhibitors of the abnormal protein that causes the condition ...
Jan 30, 2012
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Charcot-Marie-Tooth disease is an inherited disorder that leads to a gradual loss of motor neurons and, eventually, paralysis. The condition is caused by genetic mutations that disrupts cells' energy factories, called mitochondria. ...
Oct 24, 2016
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In 2015, researchers at UC San Francisco found a structure inside of tumor cells that biologists had never seen before. Even more surprising, a closer examination of the structure revealed that it contained signaling proteins known ...
May 12, 2021
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A research team led by the Duke-NUS Graduate Medical School (Duke-NUS) in Singapore has identified ways to inhibit the function of a key protein linked to stem cell-like behavior in terminal-stage chronic myeloid leukemia ...
Jun 3, 2013
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(HealthDay)—For patients with lumbar spondylosis or spondylolisthesis of the lowest lumbar levels who undergo open anterior lumbar interbody fusion (ALIF), use of recombinant human bone morphogenetic protein-2 (rhBMP-2) ...
Dec 29, 2012
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Researchers have discovered a novel role for Mitofusin 2, and the findings may point to a new treatment for patients with diseases caused by loss of the mitochondrial protein. The study appears in The Journal of Cell Biology ...
Feb 16, 2015
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Bone morphogenetic proteins, commonly used off-label to enhance pediatric spinal fusion (spinal arthrodesis), did not improve revision rates for pediatric spinal fusion, according to a study presented on March 14 at the American ...
Mar 14, 2017
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It sounds like a plot from a Quentin Tarantino movie—something sets off natural killers and sends them on a killing spree.
Jun 16, 2021
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A consortium of researchers led by Georgetown Lombardi Comprehensive Cancer Center investigators have completed the largest analysis of a new gene fusion they believe is responsible for development of a wide spectrum of cancer ...
Apr 15, 2019
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