A medication usually used to help treat depression and anxiety disorders has the potential to help prevent heart failure, according to researchers at the University of Michigan.
Oct 1, 2012
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Over one-third of all FDA-approved drugs act on a specific family of proteins: G-protein coupled receptors (GPCRs). Drugs to treat high blood pressure, asthma, cancer, diabetes and myriad other conditions target GPCRs throughout ...
May 20, 2019
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Roughly a third of all drugs approved by the U.S. Food and Drug Administration target a large family of biomolecules, known as G protein-coupled receptors (GPCRs), whose job is to trigger cellular responses to extracellular ...
Apr 27, 2022
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(HealthDay) -- The Ras-related small GTPase, Rap1, couples to RhoA, and is involved in relocalization of G protein-coupled α2C-adrenoceptors (α2CARs) in smooth muscle cells derived from human dermal arterioles (microVSM), ...
Aug 6, 2012
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If you are a woman around 50, you might have seen advice on social media or from influencers telling you protein requirements increase dramatically in midlife. Such recommendations suggest a 70 kilogram woman needs around ...
Nov 6, 2023
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Many patients with the autoimmune disease ANCA-associated vasculitis (AAV) suffer a high risk of disease relapse despite treatment. Karolinska Institutet researchers have now identified T cells that contribute to the destruction ...
Feb 16, 2023
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Constitutively activated G proteins caused by specific mutations mediate the development of multiple malignancies. The mutated Gαq/11 are perceived as oncogenic drivers in the vast majority of uveal melanoma (UM) cases, ...
Sep 5, 2022
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Some 5.8 million Americans suffer from heart failure, a currently incurable disease. But scientists at Temple University School of Medicine's (TUSM) Center for Translational Medicine have discovered a key biochemical step ...
Mar 5, 2013
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(Medical Xpress)—The cellular gatekeepers that escort the most common pharmaceuticals into our cells continue to work within the cells as well, according to a UC San Francisco discovery that could transform drug design ...
Apr 8, 2013
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Blood vessels are extremely dynamic: depending on the external conditions, they can adapt their permeability for nutrients, their contractility, and even their shape. Unlike cardiac muscle cells, for example, the smooth muscle ...
Nov 13, 2012
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