Scientists at St. Jude Children's Research Hospital and Rockefeller University have combined their expertise to gain a better understanding of the cystic fibrosis transmembrane conductance regulator (CFTR). Mutations in CFTR ...
Mar 22, 2023
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Sodium may hold the key for scientists to develop opioids or other drugs with far fewer side effects.
Nov 30, 2022
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UF Scripps Biomedical Research scientists have a discovered a key gene that is shedding light on how people develop tolerance to pain-relievers over time, a problem that raises risk of addiction and overdose.
Aug 18, 2022
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Scientists at Scripps Research have clarified the workings of a mysterious protein called Gαo, which is one of the most abundant proteins in the brain and, when mutated, causes severe movement disorders.
Feb 3, 2021
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G protein-coupled receptors (GPCRs) are the largest family of membrane protein receptors. The proteins control how tissues and organs function. More than one-third of current drugs target these receptors.
Nov 5, 2020
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Scientists at Scripps Research have comprehensively mapped how a key class of proteins within cells regulates signals coming in from cell surface receptors.
Oct 2, 2020
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Duke University researchers have developed a synthetic molecule that selectively dampen the physiological rewards of cocaine in mice. It also may represent a new class of drugs that could be more specific with fewer side ...
May 28, 2020
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Over one-third of all FDA-approved drugs act on a specific family of proteins: G-protein coupled receptors (GPCRs). Drugs to treat high blood pressure, asthma, cancer, diabetes and myriad other conditions target GPCRs throughout ...
May 20, 2019
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Johns Hopkins Medicine scientists say that new experiments with mouse eye tissues strongly suggest that a longstanding "textbook concept" about the way a mammal's retina processes light needs a rewrite.
May 16, 2019
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The release of neurotransmitters and hormones in the body is tightly controlled by complex protein machinery embedded in cell membranes.
Mar 8, 2019
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