A team of infectious and inflammatory disease specialists affiliated with several institutions in France reports that women are more susceptible to autoimmune diseases, such as lupus, due to failed X-chromosome inactivation.
Rett syndrome is a rare, progressive neurodevelopmental disorder that typically affects girls, causing severe intellectual disability, loss of motor skills, and autism-like symptoms, and there is currently no cure. Rett syndrome ...
Jan 20, 2023
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Researchers at Massachusetts General Hospital have identified a key mechanism in X chromosome inactivation, a phenomenon that may hold clues that lead to treatments for certain rare congenital disorders. Their findings, published ...
Jun 12, 2020
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The autoimmune disease lupus, which can cause fatigue, a facial rash, and joint pain, strikes females far more often than males. Eight-five percent of people with lupus are female, and their second X chromosome seems partly ...
Apr 5, 2019
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The study, published in Science, found that individuals with certain inactive genes, or 'knockouts', did not have any related adverse health effects.
Mar 8, 2016
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New initiatives by the National Center for Advancing Translational Sciences (NCATS) to use gene therapy approaches to treat rare diseases and especially promising aspects of gene transfer and gene editing technology, such ...
Feb 24, 2016
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DNA damage can lead to gene inactivation or deregulation and cause various diseases such as cancer; however, many DNA repair mechanisms allow cells to survive against such damage. A study lead by Antoine Simoneau of the laboratory ...
Jan 28, 2016
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