Genetics

Lifestyle influences metabolism via DNA methylation

An unhealthy lifestyle leaves traces in the DNA. These may have specific effects on metabolism, causing organ damage or disease. Scientists of Helmholtz Zentrum München have now identified 28 DNA alterations associated with ...

Oncology & Cancer

Defects in the packaging of DNA in malignant brain tumors

Glioblastomas grow extremely aggressively into healthy brain tissue and, moreover, are highly resistant to radiation therapy and chemotherapy. Therefore, they are regarded as the most malignant type of brain tumor. Currently ...

Oncology & Cancer

Exploring tumor evolution

Tumors are heterogeneous, which means that different parts of the same tumor can be genetically distinct. This phenomenon, known as intratumor heterogeneity, is steadily gaining in significance within the field of cancer ...

Medical research

Scientists establish model of Hutchinson-Gilford Progeria Syndrome

Scientists from A*STAR's Institute of Medical Biology (IMB) have successfully established a comprehensive model of rare accelerated ageing syndrome Hutchinson-Gilford Progeria Syndrome (HGPS), thereby opening up the possibility ...

Genetics

Twins studies to identify the molecular cause of ageing

What makes us age biologically? We have always been intrigued by this question. Yet, it remains a fundamental research challenge. Now, the EU-funded project, EurHEALTHAgeing, aims to draw together studies of early development ...

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