Genetics

Exploring the risk of ALL in children with Down syndrome

Acute lymphoblastic leukemia (ALL), is the most common childhood cancer. Children with trisomy 21 (Down syndrome) are 10 to 20 times more likely to develop ALL than children without Down syndrome. Historically, children with ...

Cardiology

Defective cilia linked to heart valve birth defects

Bicuspid aortic valve (BAV) is the most common heart valve birth defect and one of the most common birth defects of any type, affecting around 70 million people worldwide. A healthy aortic valve has three leaflets; in BAV ...

Oncology & Cancer

Cancer susceptibility genes

Genome-wide association studies (GWASs) have identified hundreds of genetic "risk" variants for human cancers. The vast majority likely contribute to cancer development by regulating the expression of other genes, but these ...

page 23 from 27