The protein Roquin plays a key role in the regulation of immune reactions. LMU researchers have now uncovered details of the mechanism by which it controls the function of regulatory T cells in the adaptive arm of the immune ...
Dec 13, 2017
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A newly-unveiled discovery, which has been four years in the making, has the potential to change the way we look at autoimmune diseases and understand how and why immune cells begin to attack different tissues in the body.
Aug 24, 2017
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Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) have discovered that the transcriptional regulator CTCF plays an essential role in antibody production. The study, led by Dr. Almudena ...
Jul 5, 2017
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Germinal centers are transient structures in the lymph nodes where antibody-producing B cells proliferate and differentiate at extraordinary rates. Germinal centers can be visually divided into a dark zone and light zone. ...
Apr 19, 2017
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When someone is HIV-positive and takes antiretroviral drugs, the virus persists in a reservoir of infected cells. Those cells hide out in germinal centers, specialized areas of lymph nodes, which most "killer" antiviral T ...
Jan 31, 2017
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B cells, the lymphocytes best known for making antibodies, live a complex life. They start developing in the bone marrow and then move through the spleen, lymph nodes and blood, taking on tasks that range from recognizing ...
Jan 23, 2017
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The inside of our small intestine teems with microbes – our gut microbiome – while just across a thin barrier, the immune system patrols and prepares for battle.
Nov 3, 2016
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When it comes to selecting for B cells that produce antibodies to hostile viruses and bacteria, the immune system hedges its bets. Within the germinal centers that form in the body's lymph nodes during an immune response ...
Feb 18, 2016
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