When it comes to selecting for B cells that produce antibodies to hostile viruses and bacteria, the immune system hedges its bets. Within the germinal centers that form in the body's lymph nodes during an immune response ...
Feb 18, 2016
0
54
Germinal centers (GCs) are specialized microenvironments where antigen (Ag)-specific B cells undergo antibody affinity maturation and clonal expansion. Positive selection of high-affinity GC B cells is driven by Ag internalization ...
Nov 15, 2023
0
0
Plasma B cells, which move through the body releasing antibodies, are an important component of the body's fight against viral infections and other invaders. They are relatively rare, however, and increasing their ranks is ...
Apr 18, 2018
0
98
When we encounter a pathogen, the immune system is usually able to respond quickly and forcefully to protect us from infection. Some of its preparedness is inherent in the process by which white blood cells called B cells ...
Jan 11, 2018
0
0
The protein Roquin plays a key role in the regulation of immune reactions. LMU researchers have now uncovered details of the mechanism by which it controls the function of regulatory T cells in the adaptive arm of the immune ...
Dec 13, 2017
0
4
Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) have discovered that the transcriptional regulator CTCF plays an essential role in antibody production. The study, led by Dr. Almudena ...
Jul 5, 2017
0
0
Germinal centers are transient structures in the lymph nodes where antibody-producing B cells proliferate and differentiate at extraordinary rates. Germinal centers can be visually divided into a dark zone and light zone. ...
Apr 19, 2017
0
0
The inside of our small intestine teems with microbes – our gut microbiome – while just across a thin barrier, the immune system patrols and prepares for battle.
Nov 3, 2016
0
76
