Medical research

Scientists link 'hunger hormone' to memory in Alzheimer's study

Scientists at The University of Texas at Dallas have found evidence suggesting that resistance to the "hunger hormone" ghrelin in the brain is linked to the cognitive impairments and memory loss associated with Alzheimer's ...

Neuroscience

'Hunger hormone' enhances memory

A team of neuroscience researchers at the University of Southern California have identified a surprising new role for the "hunger hormone" ghrelin. Ghrelin has previously been recognized for its unique role in sending hunger ...

Medical research

Gut hormone increases response to food

The holiday season is a hard one for anyone watching their weight. The sights and smells of food are hard to resist. One factor in this hunger response is a hormone found in the stomach that makes us more vulnerable to tasty ...

Medical research

Targeting a hunger hormone to treat obesity

About 64 per cent of Canadian adults are overweight or obese, according to Health Canada. That's a problem, because obesity promotes the emergence of chronic diseases such as type 2 diabetes, heart disease and some cancers.

Neuroscience

Hormones that are released during hunger affect decision making

Never make a decision when you are hungry. The hormone ghrelin - that is released before meals and known to increase appetite - has a negative effect on both decision making and impulse control. Such were the results of a ...

Psychology & Psychiatry

Ghrelin stimulates an appetite for drinking alcohol

Ghrelin is a hormone released by the stomach and it stimulates appetite and food intake. Alcohol is commonly viewed as a psychoactive substance that primarily affects brain function, but it is also a highly caloric food.

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Ghrelin

Ghrelin is a 28 amino acid peptide and hormone that is produced mainly by P/D1 cells lining the fundus of the human stomach and epsilon cells of the pancreas that stimulates hunger. Ghrelin levels increase before meals and decrease after meals. It is considered the counterpart of the hormone leptin, produced by adipose tissue, which induces satiation when present at higher levels. In some bariatric procedures, the level of ghrelin is reduced in patients, thus causing satiation before it would normally occur.

Ghrelin is a potent stimulator of growth hormone from the anterior pituitary gland. The ghrelin receptor is a G protein-coupled receptor, known as the growth hormone secretagogue receptor. Ghrelin binds to the GHSR1a splice-variant of this receptor which is present in high density in the hypothalamus, pituitary as well as vagal afferent cell bodies and vagal afferent endings throughout the gastro-intestinal tract

Ghrelin plays a significant role in neurotrophy, particularly in the hippocampus, and is essential for cognitive adaptation to changing environments and the process of learning. Recently, ghrelin has been shown to activate the endothelial isoform of nitric oxide synthase in a pathway that depends on various kinases including Akt.

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