Since the 1930s, scientists have explored a virus called LCMV (short for lymphocytic choriomeningitis virus) to reveal the hidden workings of the immune system. The virus is carried by rodents, which makes it a useful tool ...
Mar 28, 2023
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An international panel led by a pediatric neuroimmune expert and co-director of the Neuroscience Center at Children's Hospital of Philadelphia (CHOP) has established new criteria for properly diagnosing myelin oligodendrocyte ...
Feb 16, 2023
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Scientists at La Jolla Institute for Immunology (LJI) have uncovered the structure and function of the first FDA-approved treatment for Zaire ebolavirus (Ebola virus).
Jan 30, 2023
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A new study from scientists at La Jolla Institute for Immunology (LJI) gives researchers a guide to neutralizing Lassa virus using a trio of rare antibodies isolated from survivors of Lassa virus infection.
Oct 26, 2022
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Rabies virus kills a shocking 59,000 people each year, many of them children. Some victims, especially kids, don't realize they've been exposed until it is too late. For others, the intense rabies treatment regimen is out ...
Jun 17, 2022
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In a bit of "reverse engineering" research using brain tissues from five people who died with Alzheimer's disease, Johns Hopkins Medicine researchers say they discovered that a special sugar molecule could play a key role ...
May 27, 2022
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A study conducted by a consortium of Brazilian researchers has demonstrated that a hyperimmune serum consisting of purified antibody fragments produced in horses may be an efficient approach to combat COVID-19. Tests conducted ...
Oct 26, 2021
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Cytosolic peptide:N-glycanase (NGLY1) is a widely conserved enzyme involved in de–N-glycosylation of N-glycosylated proteins. Mutations in the human NGLY1 gene cause global developmental delay and multisystemic symptoms, ...
Jul 6, 2021
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A team of SMU biological scientists has confirmed that P-glycoprotein (P-gp) has the ability to remove from the brain a toxin that is associated with Alzheimer's disease.
Jun 16, 2021
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Scientists at Scripps Research have unveiled a new Ebola virus vaccine design, which they say has several advantages over standard vaccine approaches for Ebola and related viruses that continue to threaten global health.
May 12, 2021
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Glycoproteins are proteins that contain oligosaccharide chains (glycans) covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending extracellularly, the extracellular segments are often glycosylated. Glycoproteins are often important integral membrane proteins, where they play a role in cell–cell interactions. Glycoproteins also occur in the cytosol, but their functions and the pathways producing these modifications in this compartment are less well-understood.
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