Arthritis & Rheumatism

Gout diagnoses rising worldwide

The prevalence of gout—a form of arthritis characterized by severe pain, redness, and tenderness in joints—increased across the world at an alarming rate from 1990 to 2017, according to an analysis published in Arthritis ...

Arthritis & Rheumatism

ACR releases gout management guideline

Today, the American College of Rheumatology (ACR) released the 2020 Guideline for the Management of Gout. The updated guideline reflects new clinical evidence that became available since the ACR last released a treatment ...

Medications

Amlodipine better BP drug for lower long-term risk for gout

(HealthDay)—The antihypertensive medication amlodipine is associated with a lower risk for gout compared with other antihypertensive agents, according to a study published online Jan. 20 in the Journal of Hypertension.

Diseases, Conditions, Syndromes

Blood pressure drug linked to lower risk of gout

Affecting more than 7 million adults in the United States, gout is characterized by a sudden onset of pain, swelling and stiffness in the joints and caused by the formation of urate crystal in small spaces between joints ...

Health

Gout incidence down with SGLT2 inhibitors in type 2 diabetes

Adults with type 2 diabetes newly prescribed a sodium-glucose cotransporter-2 (SGLT2) inhibitor have a lower incidence of gout than those prescribed a glucagon-like peptide-1 (GLP-1) receptor agonist, according to a study ...

Arthritis & Rheumatism

Study identifies potential new target for treatment of gout

Researchers at Washington State University Health Sciences Spokane and elsewhere have identified a new therapeutic target for the treatment of gout, a common type of arthritis that causes episodes of painful and stiff joints.

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Gout

Gout (also known as podagra when it involves the big toe) is a medical condition usually characterized by recurrent attacks of acute inflammatory arthritis—a red, tender, hot, swollen joint. The metatarsal-phalangeal joint at the base of the big toe is the most commonly affected (approximately 50% of cases). However, it may also present as tophi, kidney stones, or urate nephropathy. It is caused by elevated levels of uric acid in the blood which crystallize and are deposited in joints, tendons, and surrounding tissues.

Diagnosis is confirmed clinically by the visualization of the characteristic crystals in joint fluid. Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, or colchicine improves symptoms. Once the acute attack has subsided, levels of uric acid are usually lowered via lifestyle changes, and in those with frequent attacks allopurinol or probenecid provide long-term prevention.

Gout has increased in frequency in recent decades affecting approximately one to two percent of the Western population at some point in their lives. The increase is believed to be due to increasing risk factors in the population, such as metabolic syndrome, longer life expectancy and changes in diet. Gout was historically known as "the disease of kings" or "rich man's disease".

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