UCLA scientists have discovered a link between a protein and the ability of human blood stem cells to self-renew. In a study published today in the journal Nature, the team reports that activating the protein causes blood ...
Nov 28, 2019
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Dying retinal cells send out a rescue signal to recruit stem cells and repair eye damage, according to the findings of a new study published today in the journal Molecular Therapy. The findings open the door to restoring ...
Dec 1, 2020
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Researchers at Fred Hutchinson Cancer Research Center have identified a specific subset of adult blood stem cells that is exclusively responsible for repopulating the entire blood and immune system after a transplant.
Nov 1, 2017
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Adult stem cells provide the body with a reservoir from which damaged or used up tissues can be replenished. In organs like the intestines and skin, which need constant rejuvenating, these stem cells are dividing frequently. ...
Mar 3, 2016
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Genetic mutations are commonly studied because of links to diseases such as cancer; however, little is known about mutations occurring in healthy individuals. In a study published online in Genome Research, researchers detected ...
Apr 23, 2014
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Sending a manned mission to Mars requires more than a powerful launch rocket. Prep work also includes learning how a three-year space flight could affect the human body. With funding from the National Aeronautics and Space ...
Mar 8, 2017
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Fibrosis is the thickening of various tissues caused by the deposition of fibrillar extracellular matrix (ECM) in tissues and organs as part of the body's wound healing response to various forms of damage. When accompanied ...
Jul 11, 2022
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A team of researchers from the University of Cambridge, Stanford University and Washington University School of Medicine has found evidence indicating that positive selection (as opposed to drift) is the major force shaping ...
Osteoporosis is a condition marked by weak and brittle bones often leading to devastating bone fractures and other injuries. Millions of people worldwide are diagnosed with osteoporosis.
More than 300,000 people suffer a heart attack in Germany every year. In this case, the heart muscle is no longer supplied with sufficient blood and oxygen, and part of the heart muscle tissue dies and becomes scarred. The ...
Jun 17, 2022
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Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all the blood cell types including myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). The definition of hematopoietic stem cells has undergone considerable revision in the last two decades. The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. Recently, long-term transplantation experiments point toward a clonal diversity model of hematopoietic stem cells. Here, the HSC compartment consists of a fixed number of different types of HSC, each with epigenetically preprogrammed behavior. This contradicts older models of HSC behavior, which postulated a single type of HSC that can be continuously molded into different subtypes of HSCs. HSCs constitute 1:10.000 of cells in myeloid tissue.
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