Hematopoietic stem cells (HSCs) have the capacity to both self-renew and differentiate into all mature blood cell types, making them promising treatments for a variety of diseases. However, the mechanisms involved in engraftment—when ...
Mar 1, 2022
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A novel gene therapy promoted transfusion independence in more than 90 percent of adult and pediatric patients with transfusion-dependent beta-thalassemia, according to a recent clinical trial published in the New England ...
Feb 4, 2022
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Two recent discoveries by stem cell scientists at Cedars-Sinai may help make cancer treatment more efficient and shorten the time it takes for people to recover from radiation and chemotherapy.
Jan 25, 2022
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Over the past three decades, efforts to improve the results of standard treatment for patients with severe aplastic anemia have been largely unsuccessful. The phase III RACE trial, sponsored by the European Society for Blood ...
Jan 5, 2022
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Aplastic anemia (AA) is a life-threatening bone marrow disorder caused by the autoimmune destruction of hematopoietic stem and progenitor cells (HSPCs). Currently, the condition is a diagnosis of exclusion, as there are no ...
Sep 20, 2021
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Hematopoietic stem cells—the precursors to blood cells—have been notoriously difficult to grow in a dish, a critical tool in basic research. Scientists at University of California San Diego School of Medicine have identified ...
Aug 12, 2021
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Princess Margaret Cancer Centre researchers have made new findings which provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number ...
Aug 2, 2021
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Most people can expect to break close to two bones in their lifetime, but those with osteogenesis imperfecta—also known as brittle bone disease—can break hundreds of bones before they even hit puberty. And while healthy ...
Jul 23, 2021
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Chemotherapy is widely used to treat cancer patients. During the treatment, chemotherapeutic agents affect various biochemical processes to kill or reduce the growth of cancer cells, which divide uncontrollably in patients. ...
Jul 12, 2021
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A research collaboration based in Kumamoto University (Japan) has shown that lysine-specific demethylase 1 (LSD1), an enzyme involved in gene expression, produces individualized metabolism depending on the type of acute myeloid ...
Jul 5, 2021
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