Scientists are increasingly tracing a variety of diseases back to the so-called epigenome, a type of indexing system imposed on DNA that dictates how genes should be read by the cells. Now, a new study finds that changes ...
Nov 12, 2019
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Cancer, in all its forms, seems to always involve uncontrolled cell growth; but there are thousands of ways in which cells can lose control of their proliferation in the first place. Among a huge variety of proteins known ...
Mar 22, 2019
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A study published in Nature Communications found that an inhibitor of an enzyme called ACVR1 slows tumor growth and increases survival in an animal model of diffuse intrinsic pontine glioma (DIPG) - the most deadly brain ...
Mar 4, 2019
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The prognosis for all children diagnosed with an aggressive brain tumor known as diffuse intrinsic pontine glioma (DIPG) and similar tumors has been mostly the same: dismal.
Jan 17, 2018
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St. Jude Children's Research Hospital biologists have used engineered yeast cells to discover how a mutation that is frequently found in pediatric brain tumor high-grade glioma triggers a cascade of genomic malfunctions.
Jul 18, 2017
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A study published in Molecular Cancer Research reveals that a tumor suppressor gene p16 is turned off by a histone mutation (H3.3K27M), which is found in up to 70 percent of childhood brain tumors called diffuse intrinsic ...
Jun 6, 2017
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Epigenetics, a term coined by Conrad H. Waddington in the early 1940s, originally described the complex molecular pathways that govern how a genotype manifests as a phenotype. Over time, this definition has evolved to focus ...
May 31, 2024
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