Diseases, Conditions, Syndromes

How malaria is shaping the human genome

For millennia, malaria has been a major killer of children in Africa and other parts of the world. In doing so, it has been a major force of evolutionary selection on the human genome.

Genetics

Conspicuous tRNA lookalikes riddle the human genome

Transfer RNAs (tRNAs) are ancient workhorse molecules and part of the cellular process that creates the proteins, critical building blocks of life that keep a cell running smoothly. A new discovery suggests that the number ...

Alzheimer's disease & dementia

DNA methylation involved in Alzheimer's disease

A new study led by researchers at Brigham and Women's Hospital (BWH) and Rush University Medical Center, reveals how early changes in brain DNA methylation are involved in Alzheimer's disease. DNA methylation is a biochemical ...

Genetics

A shift in the code: New method reveals hidden genetic landscape

With three billion letters in the human genome, it seems hard to believe that adding a DNA base here or removing a DNA base there could have much of an effect on our health. In fact, such insertions and deletions can dramatically ...

Oncology & Cancer

Mobile DNA elements restructure cancer genomes

(Medical Xpress)—Researchers have found a novel mechanism that can restructure a cancer's genome and introduce hundreds of mutations. Previously overlooked through misidentification, this mechanism, a common feature of ...

Genetics

Classifying sequence variants in human disease

Sequencing an entire human genome is faster and cheaper than ever before, leading to an explosion of studies comparing the genomes of people with and without a given disease. Often clinicians and researchers studying genetic ...

Genetics

First comprehensive atlas of human gene activity released

A large international consortium of researchers has produced the first comprehensive, detailed map of the way genes work across the major cells and tissues of the human body. The findings describe the complex networks that ...

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