Diseases, Conditions, Syndromes

A risk factor for drug-induced skin disease identified

DPP-4 inhibitor (DPP-4i) is widely used to treat type 2 diabetes, but increased cases of bullous pemphigoid (BP) have been reported among patients taking the medicine. BP is the most common autoimmune blistering disorder, ...

Oncology & Cancer

Personalizing cancer treatment through machine learning

Researchers at the Cheriton School of Computer Science have applied machine learning to identify tumor-specific antigens, which could help make personalized cancer vaccines practically feasible and more accurate.

Neuroscience

Unraveling complex genetic interplay for MS risks

A WA-cohort of patients has been used to study the risk modifying role of specific genes suspected to contribute to one's predisposition to multiple sclerosis (MS).

Oncology & Cancer

Particular donor genotype lowers leukemia relapse rate

(HealthDay)—Patients with acute myeloid leukemia who receive a stem cell transplant from a donor with activating killer-cell immunoglobulin-like receptor (KIR) genotype KIR2DS1, which has ligand specificity for human leukocyte ...

Immunology

Use of stem cells, conditioning induces immune tolerance

(HealthDay) -- A novel approach using a bioengineered mobilized cellular product enriched with hematopoietic stem cells (HSCs) and tolerogenic graft facilitating cells (FCs) in combination with nonmyeloablative conditioning ...

Immunology

Scientists map the antigenic landscape

A new paper in Science Advances details how scientists have succeeded in mapping a central part of the immune system—the HLA class II molecules—while accurately predicting how they display fragments of pathogens on the ...

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