Medical research

Humanization of antibodies targeting human herpesvirus 6B

A research group led by Professor Yasuko Mori (Division of Clinical Virology, Center for Infectious Diseases, Kobe University) has succeeded in humanization of mouse antibodies that can neutralize the infection caused by ...

Diseases, Conditions, Syndromes

Synthetic antibody rapidly protects mice and monkeys from Zika

A DNA-encoded monoclonal antibody prevents Zika infection in mice and non-human primates, researchers report April 5th in the journal Molecular Therapy. Injections of synthetic DNA encoding the potent anti-Zika monoclonal ...

Diseases, Conditions, Syndromes

Denosumab promising for TDT-induced osteoporosis treatment

(HealthDay)—Denosumab (DNM), a fully human monoclonal antibody against the receptor activator of nuclear factor kappa-B ligand (RANKL), may be beneficial for managing transfusion-dependent thalassemia (TDT)-induced osteoporosis, ...

Diseases, Conditions, Syndromes

Team isolates antibodies that neutralize GI bug norovirus

Researchers at Vanderbilt University Medical Center have isolated the first human monoclonal antibodies that can neutralize norovirus, the leading cause of acute gastrointestinal illness in the world.

Diseases, Conditions, Syndromes

How the human immune system protects against Ebola

Two types of human antibodies that target different parts of the Ebola virus synergize their antiviral effects by inhibiting different steps of infection, according to a study published August 23 in the open-access journal ...

Diseases, Conditions, Syndromes

Experimental MERS treatments enter clinical trial

Enrollment has begun in an early-stage clinical trial testing the safety of two human monoclonal antibodies (mAbs) designed to treat people infected with Middle East respiratory syndrome coronavirus (MERS-CoV). The trial ...

Diseases, Conditions, Syndromes

Study seeking to isolate antibodies against rabies virus

Few people die from rabid animal bites in the United States thanks to the near-universal availability of human rabies immune globulin and rabies vaccine, which are given as separate shots as soon as possible after exposure ...

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