Cardiology

HCQ during pregnancy may prevent congenital heart block

(HealthDay)—For anti-SSA/Ro-positive mothers with a previous pregnancy complicated by congenital heart block (CHB), hydroxychloroquine may reduce the recurrence of CHB, according to a study published in the July 21 issue ...

Medications

Why lopinavir and hydroxychloroquine do not work on COVID-19

Lopinavir is a drug against HIV; hydroxychloroquine is used to treat malaria and rheumatism. Until recently, both drugs were regarded as potential agents in the fight against the coronavirus SARS-CoV-2. A research group from ...

Diseases, Conditions, Syndromes

Swiss giant Novartis halts COVID-19 hydroxychloroquine study

Swiss pharmaceuticals giant Novartis has decided to halt a clinical trial of hydroxychloroquine as a treatment for COVID-19, citing problems in recruiting enough patients for the study of the controversial drug.

Diseases, Conditions, Syndromes

Hydroxychloroquine COVID-19 prevention trials incomplete: WHO

Hydroxychloroquine can be ruled out as a treatment for hospitalised COVID-19 patients—but the World Health Organization said Thursday it was aware of ongoing trials into its value as a preventative measure.

Diseases, Conditions, Syndromes

WHO halts hydroxychloroquine trials on COVID-19 patients

The World Health Organization decided Wednesday to halt trials of hydroxychloroquine as a potential treatment for hospitalised COVID-19 patients, finding it did not reduce the mortality rate.

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Hydroxychloroquine

Hydroxychloroquine is an antimalarial drug, sold under the trade names Plaquenil,Axemal(In India), Dolquine, and Quensyl, also used to reduce inflammation in the treatment of rheumatoid arthritis (see disease-modifying antirheumatic drugs) and lupus. Hydroxychloroquine differs from chloroquine by the presence of a hydroxyl group at the end of the side chain: The N-ethyl substituent is beta-hydroxylated. It is available for oral administration as hydroxychloroquine sulfate (plaquenil) of which 200 mg contains 155 mg base in chiral form. Hydroxychloroquine has similar pharmacokinetics to chloroquine, with quick gastrointestinal absorption and is eliminated by the kidney. Cytochrome P450 enzymes (CYP 2D6, 2C8, 3A4 and 3A5) N-desethylated Hydroxychloroquine to Ndesethylhydroxychloroquine. ,

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