While the medical community agrees that immune cells inside a tumor leads to improved health outcome, for a subset of colorectal cancer patients, having too much of a good thing—too many immune cells—is a strong predictor ...
Sep 16, 2019
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A new liquid biopsy test could detect microsatellite instability (MSI) and tumor mutational burden (TMB), indicating that it could help determine which patients are likely to respond to immune checkpoint inhibitors, according ...
Sep 11, 2019
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Immune checkpoint inhibitors are a type of therapy that uses the immune system to fight cancer. They have been hailed as game changing, garnering a Nobel Prize last year and quickly becoming the standard of care for many ...
Sep 5, 2019
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Immune checkpoint inhibitors (ICIs) are an emerging type of cancer immunotherapy that uses the immune system to attack cancer cells. However, in some patients they cause the immune system to attack healthy cells, leading ...
Jun 11, 2019
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In a study led by UCLA investigators, treatment with the immunotherapy drug pembrolizumab helped more than 15 percent of people with advanced non-small cell lung cancer live for at least five years—and 25 percent of patients ...
Jun 3, 2019
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University of Pennsylvania researchers are reporting early but encouraging results from two small ongoing studies of experimental treatments for metastatic pancreatic cancer.
Apr 3, 2019
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An attractive approach to liver cancer treatment is to bolster the body's own immune defenses. Now an international team involving A*STAR researchers has genetically engineered human T cells to endow them with both specificity ...
Mar 18, 2019
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Immune checkpoint inhibitors, such as the anti-PD-1 antibody pembrolizumab, have become important tools for managing non-small-cell lung cancer (NSCLC). Assessing the level of programmed death ligand 1 (PD-L1) expressed by ...
Feb 13, 2019
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In an article recently published in JCI Insight, researchers from the University of Alabama at Birmingham and Vanderbilt University have identified checkpoint inhibitor resistance mechanisms in many solid tumor cancers, including ...
Jan 23, 2019
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There is a significant need for new treatments for patients with relapsed acute myeloid leukemia, a rare cancer of the blood that is more common in older adults. UNC Lineberger Comprehensive Cancer Center researchers recently ...
Jan 4, 2019
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