Oncology & Cancer

Putting the STING into cancer immunotherapy

Immune checkpoint blockade therapies have been revolutionary in the treatment of some cancer types, emerging as one of the most promising treatments for diseases such as melanoma, colon cancer and non-small cell lung cancer.

Genetics

Big data provides clues for characterizing immunity in Japanese

Although genes are distributed widely across chromosomes, many genes related to the immune system are clustered together on human chromosome 6 in a segment called the major histocompatibility complex (MHC) region. The density ...

Immunology

Study unveils T cell signaling process central to immune response

The immune system cells known as T cells play a central role in the body's ability to fight infections and cancer. For decades, however, details of the molecular signaling process that leads to T cell activation have remained ...

Medical research

New detailed immune-profiling method uses only DNA from blood

Flow cytometry is a powerful and complex technology used to count, sort or measure characteristics of cells and to detect biomarkers. It's also widely used in research, as well as in clinical studies and diagnosis of disorders ...

Immunology

The PANoptosome: A new frontier in innate immune responses

St. Jude Children's Research Hospital immunologists have identified how immune sensors in infected cells organize and launch a multi-faceted innate immune response to infections with live viruses and bacteria. The discovery ...

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