Immunology

The wrong track: How papillomaviruses trick the immune system

Specific antibodies protect us against viral infections—or do they? Researchers at the German Cancer Research Center (DKFZ) studied the immune response to papillomaviruses in mice and discovered a hitherto unknown mechanism ...

Diseases, Conditions, Syndromes

Cellular antiviral defenses

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that regulates levels of both aberrant and wild-type cellular RNAs. It also contributes to antiviral immunity against select plant and human RNA viruses. However, ...

Diseases, Conditions, Syndromes

Freeze-framing the shape-shifting SARS-CoV-2 spike protein

The rod-like spike proteins on the surface of SARS CoV-2 are the tip of the spear of the COVID-19 pandemic. The spikes bind to human cells via the ACE2 receptor and then dramatically change shape, jack-knifing to fuse the ...

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