The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses. Upon mutation-induced loss of TBK1 function, patients show an increased susceptibility to viral ...
Mar 10, 2023
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Many patients with the autoimmune disease ANCA-associated vasculitis (AAV) suffer a high risk of disease relapse despite treatment. Karolinska Institutet researchers have now identified T cells that contribute to the destruction ...
Feb 16, 2023
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A combination of two next-generation immunotherapy drugs has shown promising clinical activity in treating patients with refractory metastatic colorectal cancer, a disease which has not previously responded well to immunotherapies, ...
Jan 23, 2023
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Northwestern Medicine scientists have discovered the pathways through which autoantibodies—immune proteins that mistakenly attack a person's own body—leak out of blood vessels and cause primary graft dysfunction in some ...
Nov 18, 2022
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Humans can smell over 1 trillion odours. But no two people will react in quite the same way to the same smell. While there are some smells almost everyone agrees are unpleasant (such as paint thinner or rotten food), our ...
Oct 21, 2022
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Patients with myeloma whose tumor immune microenvironments had a more diverse baseline T-cell repertoire, fewer markers of immune cell exhaustion, and distinct changes to immune cell populations were more likely to have longer ...
Aug 30, 2022
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Research from the laboratories of Dr. André Veillette, Director of Research in Molecular Oncology at the Montreal Clinical Research Institute (IRCM) and Professor and Researcher in the Department of Medicine at the Université ...
Aug 8, 2022
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Scientists at St. Jude Children's Research Hospital are improving chimeric antigen receptor (CAR) T-cell therapy. Their new simplified approach selected for an advantageous T-cell type and showed promise in the lab against ...
Aug 5, 2022
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Scientific advancements have often been held back by the need for high volumes of data, which can be costly, time-consuming, and sometimes difficult to collect. But there may be a solution to this problem when investigating ...
Jul 20, 2022
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T cells are usually good at eliminating diseased cells, but they seem to fail when it comes to tumor cells. In JCI Insight, MDC teams led by Armin Rehm and Uta Höpken describe what inhibits this immune function, and how ...
Jun 13, 2022
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