Immunology

Food allergies and multiple sclerosis: study reveals a new link

Like many other medical conditions, the mechanism of multiple sclerosis remains an enigma—a puzzle composed of complex genetic and environmental factors. A key piece to this puzzle is the immune system, which is also responsible ...

Immunology

How the 'Iron Man' of immune cells helps T cells fight infection

The immune system's killer T cells are crucial in fighting viral infections. A fraction of them, called 'memory cells', live on once infection is controlled in order to fight re-infection by the same virus. They are of great ...

Diseases, Conditions, Syndromes

'Killer' cells raise hope of universal flu vaccine

Scientists said Monday they had discovered immune cells that can fight all known flu viruses in what was hailed as an "extraordinary breakthrough" that could lead to a universal, one-shot vaccine against the killer disease.

Medical research

CRISPR gene editing makes stem cells 'invisible' to immune system

UC San Francisco scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally "invisible" to the immune system, a feat of biological engineering that, in laboratory ...

Diseases, Conditions, Syndromes

Influenza and the common cold – two different diseases

There is a lack of information about the difference between influenza and the common cold. Most people struggle to distinguish between these two conditions, and this often leads to irritation and the perpetuation of myths. ...

Cancer

Why some brain tumors respond to immunotherapy

Columbia researchers have learned why some glioblastomas—the most common type of brain cancer—respond to immunotherapy. The findings could help identify patients who are most likely to benefit from treatment with immunotherapy ...

Cancer

Immune stimulant molecule shown to prevent cancer

A research team at the University of Louisville has discovered that an immune checkpoint molecule they developed for cancer immunotherapy, also protects against future development of multiple types of cancer when administered ...

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Immune system

An immune system is a collection of biological processes within an organism that protects against disease by identifying and killing pathogens and tumour cells. It detects a wide variety of agents, from viruses to parasitic worms, and needs to distinguish them from the organism's own healthy cells and tissues in order to function properly. Detection is complicated as pathogens can evolve rapidly, producing adaptations that avoid the immune system and allow the pathogens to successfully infect their hosts.

To survive this challenge, multiple mechanisms evolved that recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess enzyme systems that protect against viral infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants, fish, reptiles, and insects. These mechanisms include antimicrobial peptides called defensins, phagocytosis, and the complement system. Vertebrates such as humans have even more sophisticated defense mechanisms. The immune systems of vertebrates consist of many types of proteins, cells, organs, and tissues, which interact in an elaborate and dynamic network. As part of this more complex immune response, the human immune system adapts over time to recognise specific pathogens more efficiently. This adaptation process is referred to as "adaptive immunity" or "acquired immunity" and creates immunological memory. Immunological memory created from a primary response to a specific pathogen, provides an enhanced response to secondary encounters with that same, specific pathogen. This process of acquired immunity is the basis of vaccination.

Disorders in the immune system can result in disease. Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. Immunodeficiency can either be the result of a genetic disease, such as severe combined immunodeficiency, or be produced by pharmaceuticals or an infection, such as the acquired immune deficiency syndrome (AIDS) that is caused by the retrovirus HIV. In contrast, autoimmune diseases result from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's Thyroiditis, rheumatoid arthritis, diabetes mellitus type 1 and lupus erythematosus. Immunology covers the study of all aspects of the immune system which has significant relevance to human health and diseases. Further investigation in this field is expected to play a serious role in promotion of health and treatment of diseases.

This text uses material from Wikipedia, licensed under CC BY-SA