Diseases, Conditions, Syndromes

Consumer Health: What's the difference between heartburn and GERD?

Heartburn—that burning pain in your chest after eating certain foods or when you lie down in the evening—is a common complaint and usually no cause for alarm. Heartburn occurs when stomach acid backs up into the esophagus, ...

Diseases, Conditions, Syndromes

Understanding how hormones influence anemia

Northwestern Medicine scientists have uncovered how peptides produced by bones during inflammation prevent anemia in mice, according to a recent study published in the journal Blood.

Obstetrics & gynaecology

How magnesium sulfate benefits preterm babies

Being born too soon exposes babies to many dangerous health conditions, and researchers are tackling one of them by finding out how magnesium sulfate can protect the health of the preterm brain.

Oncology & Cancer

Study: B cells promote liver cancer with dangerous dual strategy

Inflammatory fatty liver disease (NASH, non alcoholic steatohepatitis) and the resulting liver cancer are driven by auto-aggressive T cells. Scientists from the German Cancer Research Center (DKFZ) now show what is behind ...

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Inflammation

Inflammation (Latin, inflamatio, to set on fire) is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue. Inflammation is not a synonym for infection. Even in cases where inflammation is caused by infection, the two are not synonymous: infection is caused by an exogenous pathogen, while inflammation is the response of the organism to the pathogen.

In the absence of inflammation, wounds and infections would never heal and progressive destruction of the tissue would compromise the survival of the organism. However, an inflammation that runs unchecked can also lead to a host of diseases, such as hay fever, atherosclerosis, and rheumatoid arthritis. It is for that reason that inflammation is normally closely regulated by the body.

Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes from the blood into the injured tissues. A cascade of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. Prolonged inflammation, known as chronic inflammation, leads to a progressive shift in the type of cells which are present at the site of inflammation and is characterised by simultaneous destruction and healing of the tissue from the inflammatory process.

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