Inflammatory disorders

Better treatment for people with inflammatory bowel disease

Finding the right treatment for people living with chronic intestinal inflammation, also known as inflammatory bowel disease (IBD), might soon be getting easier. World IBD Day happens on 19 May each year, with the goal to ...

Inflammatory disorders

Antioxidants in corn line could aid human IBD protection, therapy

Flavonoids from a specific line of corn act as anti-inflammatory agents in the guts of mice with an inflammatory-bowel-disease-like condition, according to a team of researchers who said flavonoid-rich corn should be studied ...

Diseases, Conditions, Syndromes

Superbug impact on the gut

Monash University researchers have discovered that the devastating bacterial superbug Clostridioides difficile hijacks the human wound healing system in order to cause serious and persistent disease, opening up the development ...

Alzheimer's disease & dementia

Inflammatory bowel disease linked to doubling in dementia risk

Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is linked to a more than doubling in the risk of developing dementia, finds research published online in the journal Gut.

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Inflammation

Inflammation (Latin, inflamatio, to set on fire) is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue. Inflammation is not a synonym for infection. Even in cases where inflammation is caused by infection, the two are not synonymous: infection is caused by an exogenous pathogen, while inflammation is the response of the organism to the pathogen.

In the absence of inflammation, wounds and infections would never heal and progressive destruction of the tissue would compromise the survival of the organism. However, an inflammation that runs unchecked can also lead to a host of diseases, such as hay fever, atherosclerosis, and rheumatoid arthritis. It is for that reason that inflammation is normally closely regulated by the body.

Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes from the blood into the injured tissues. A cascade of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. Prolonged inflammation, known as chronic inflammation, leads to a progressive shift in the type of cells which are present at the site of inflammation and is characterised by simultaneous destruction and healing of the tissue from the inflammatory process.

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