A new method of precisely targeting troublesome cells for death using light could unlock new understanding of and treatments for cancer and inflammatory diseases, University of Illinois Urbana-Champaign researchers report.
Jul 1, 2024
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Researchers probing the next frontiers in cancer therapy have turned to bacteria given their ability to inhibit tumor proliferation by colonizing tumors. Crucially, the Achilles heel of this approach is suboptimal treatment ...
Jul 1, 2024
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Researchers at the University of Alabama at Birmingham have found a potential link between putative retinal gliosis and Alzheimer's disease. The study, published in Investigative Ophthalmology & Visual Science, demonstrates ...
Jun 26, 2024
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Researchers are exploring natural compounds as potential alternatives to conventional antidepressants, which often yield inconsistent results. Compounds that activate the TrkB receptor are of particular interest, as this ...
Jun 25, 2024
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Asthma patients experience respiratory distress due to allergens like house dust mites or pollen. However, the various triggers for asthma share a common pathway involving the release of proteins called type-2 cytokines by ...
Jun 24, 2024
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Due to differences in clinical presentation and limited knowledge, diagnosing Sjögren's disease in children can be challenging. Although dysregulation of multiple immune response pathways has been shown in adults, few studies ...
Jun 14, 2024
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The nasal microbiota of intensive care unit (ICU) patients effectively distinguishes sepsis from non-septic cases and outperforms analyzing the gut microbiota to predict sepsis, according to a new study published in Microbiology ...
Jun 12, 2024
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Researchers have just taken the most fine-grained look to date at inflammatory pain: increased sensitivity to pain that follows an immune response to a wound, infection, sunburn, arthritis, or other trigger.
Jun 5, 2024
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Metabolic dysfunction-associated steatotic liver disease (MASLD), an escalating metabolic disorder, poses a severe challenge to global health. However, our understanding of its underlying molecular mechanisms remains limited.
Jun 3, 2024
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A new study to be presented at the SLEEP 2024 annual meeting, held in Houston, Texas, June 1–5, found that low-dose acetylsalicylic acid, also known as aspirin, can reduce inflammatory responses to sleep restriction.
Jun 3, 2024
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Inflammation (Latin, inflamatio, to set on fire) is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue. Inflammation is not a synonym for infection. Even in cases where inflammation is caused by infection, the two are not synonymous: infection is caused by an exogenous pathogen, while inflammation is the response of the organism to the pathogen.
In the absence of inflammation, wounds and infections would never heal and progressive destruction of the tissue would compromise the survival of the organism. However, an inflammation that runs unchecked can also lead to a host of diseases, such as hay fever, atherosclerosis, and rheumatoid arthritis. It is for that reason that inflammation is normally closely regulated by the body.
Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes from the blood into the injured tissues. A cascade of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. Prolonged inflammation, known as chronic inflammation, leads to a progressive shift in the type of cells which are present at the site of inflammation and is characterised by simultaneous destruction and healing of the tissue from the inflammatory process.
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