Diseases, Conditions, Syndromes

Today's seasonal flu may descend from 1918 pandemic strain

Today's H1N1 flu—commonly known as the swine flu—appears to be a direct descendent of the influenza virus that caused the catastrophic 1918 pandemic, a new analysis shows.

Medications

Drug combination fails to improve outcomes in influenza

A new combination of antiviral drugs did not improve clinical outcomes in hospitalized patients with severe influenza, according results from a recent clinical trial published in The Lancet Infectious Diseases.

Diseases, Conditions, Syndromes

First human case of avian influenza A(H5N1) in Europe

Following an outbreak of highly pathogenic avian influenza A(H5N1) in a flock of around 125 Muscovy ducks in a domestic setting in South West England on 22 December 2021, the virus was later also confirmed in the asymptomatic ...

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Orthomyxoviridae

Influenzavirus A Influenzavirus B Influenzavirus C Isavirus Thogotovirus

The Orthomyxoviridae (orthos, Greek for "straight"; myxa, Greek for "mucus") are a family of RNA viruses that includes five genera: Influenzavirus A, Influenzavirus B, Influenzavirus C, Isavirus and Thogotovirus. The first three genera contain viruses that cause influenza in vertebrates, including birds (see also avian influenza), humans, and other mammals. Isaviruses infect salmon; thogotoviruses infect vertebrates and invertebrates, such as mosquitoes and sea lice.

The three genera of Influenzavirus, which are identified by antigenic differences in their nucleoprotein and matrix protein infect vertebrates as follows:

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