Diseases, Conditions, Syndromes

Q&A: Ethical approaches to mitigate H5N1 bird flu

In recent months, H5N1 or HPAI (highly pathogenic avian influenza), commonly referred to as bird flu, has become a growing concern for public health authorities. Mitigation efforts, including surveillance and testing of livestock ...

Diseases, Conditions, Syndromes

Monitoring the H5N1 avian influenza, bird flu, outbreak

The Centers for Disease Control and Prevention continues to actively monitor the ongoing outbreak of H5N1 avian influenza, also known as bird flu, and says that the public health risk remains low.

Diseases, Conditions, Syndromes

Researchers develop experimental mRNA avian flu vaccine

An experimental mRNA vaccine against avian influenza virus H5N1 is highly effective in preventing severe illness and death in preclinical models. The vaccine could potentially help manage the outbreak of the H5N1 virus currently ...

Diseases, Conditions, Syndromes

Vigilance needed to avert spread of bird flu to humans

Health experts are calling for tighter biosecurity measures in global poultry production, from farms to markets, to monitor bird flu (avian influenza) following its spread among dairy cows in the United States.

Diseases, Conditions, Syndromes

Preparedness for HPAI A(H5N1) virus varies across jurisdictions

Variation is seen in preparedness and response to highly pathogenic avian influenza (HPAI) A(H5N1) viruses, according to a research letter published online May 21 in the Journal of the American Medical Association.

Medical research

Drug-like inhibitor shows promise in preventing flu

Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place? Now, scientists at Scripps Research and the Albert Einstein ...

Diseases, Conditions, Syndromes

Five things to know about bird flu

As a new virus takes center stage at the heart of a global outbreak, it's easy to get flashbacks of March 2020.

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Influenza

Influenza, commonly referred to as the flu, is an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses), that affects birds and mammals. The name influenza comes from the Italian influenza, meaning "influence" (Latin: influentia). The most common symptoms of the disease are chills, fever, sore throat, muscle pains, severe headache, coughing, weakness and general discomfort. Fever and coughs are the most frequent symptoms. In more serious cases, influenza causes pneumonia, which can be fatal, particularly for the young and the elderly. Although it is often confused with other influenza-like illnesses, especially the common cold, influenza is a much more severe disease than the common cold and is caused by a different type of virus. Influenza may produce nausea and vomiting, particularly in children, but these symptoms are more common in the unrelated gastroenteritis, which is sometimes called "stomach flu" or "24-hour flu".

Typically, influenza is transmitted through the air by coughs or sneezes, creating aerosols containing the virus. Influenza can also be transmitted by bird droppings, saliva, nasal secretions, feces and blood. Infection can also occur through contact with these body fluids or through contact with contaminated surfaces. Airborne aerosols have been thought to cause most infections, although which means of transmission is most important is not absolutely clear. Influenza viruses can be inactivated by sunlight, disinfectants and detergents. As the virus can be inactivated by soap, frequent hand washing reduces the risk of infection.

Influenza spreads around the world in seasonal epidemics, resulting in the deaths of hundreds of thousands annually — millions in pandemic years. Three influenza pandemics occurred in the 20th century and killed tens of millions of people, with each of these pandemics being caused by the appearance of a new strain of the virus in humans. Often, these new strains appear when an existing flu virus spreads to humans from other animal species, or when an existing human strain picks up new genes from a virus that usually infects birds or pigs. An avian strain named H5N1 raised the concern of a new influenza pandemic, after it emerged in Asia in the 1990s, but it has not evolved to a form that spreads easily between people. In April 2009 a novel flu strain evolved that combined genes from human, pig, and bird flu, initially dubbed "swine flu", emerged in Mexico, the United States, and several other nations. WHO officially declared the outbreak to be a "pandemic" on June 11, 2009.

Vaccinations against influenza are usually given to people in developed countries and to farmed poultry. The most common human vaccine is the trivalent influenza vaccine (TIV) that contains purified and inactivated material from three viral strains. Typically, this vaccine includes material from two influenza A virus subtypes and one influenza B virus strain. The TIV carries no risk of transmitting the disease, and it has very low reactivity. A vaccine formulated for one year may be ineffective in the following year, since the influenza virus evolves rapidly, and new strains quickly replace the older ones. Antiviral drugs can be used to treat influenza, with neuraminidase inhibitors being particularly effective.

This text uses material from Wikipedia, licensed under CC BY-SA