Medical research

Whole-blood RNA profiling of severe COVID cases

Just as a recipe contains the instructions needed to make a dish, messenger ribonucleic acid (mRNA) sequences in the body contain the information needed to make proteins. Changes in the expression of specific mRNAs and short ...

Medical research

Multiple sclerosis drug works in a surprising way

Drugs called interferon betas are common treatments for multiple sclerosis (MS), reducing relapses and slowing motor function decline. Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce ...

Diseases, Conditions, Syndromes

SARS-CoV-2 variants have developed resistance to human interferons

Researchers at the University of Colorado Anschutz Medical Campus have investigated how antiviral proteins called interferons interact with SARS-CoV-2, the cause of COVID-19. The study, published in Proceedings of the National ...

Immunology

Cytokines found to contribute to IgA nephropathy

Some cytokines can enhance the production of aberrantly O-glycosylated IgA1, the main autoantigen in IgA nephropathy. The mechanism behind this observation is described in the Journal of Interferon & Cytokine Research (JICR).

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