Diseases, Conditions, Syndromes

COVID-19 virus helps block host immunity

SARS-CoV-2, the virus that causes COVID-19, blocks the processes of innate immune activation that normally direct the production and/or signaling of type I interferon (IFN-I) by the infected cell and tissues. IFN-I is a key ...

Inflammatory disorders

New research defines role of long noncoding RNAs in inflammation

Inflammation and immune system activation are complex processes controlled by elaborate signaling pathways and hundreds of genes that are turned on and off in response to external stimuli such as bacteria or viruses. A class ...

Diseases, Conditions, Syndromes

Will new drugs block hepatitis C virus in its tracks?

Targeted multi-drug treatments for hepatitis C patients that could stop the virus in its tracks have come a step closer, thanks to researchers at the University of Leeds, UK.

Neuroscience

Study of daclizumab yields mixed results in multiple sclerosis

(HealthDay)—Multiple sclerosis patients taking daclizumab high yield process (HYP), a humanized monoclonal antibody that binds to CD25 (alpha subunit of the interleukin-2 receptor) and modulates interleukin-2 signaling, ...

Oncology & Cancer

Improving interferon therapy for blood cancers

[Northwestern Medicine investigators have discovered a novel signaling pathway activated by interferons, a group of immune system proteins, that suppresses the anti-tumor response of interferons in patients with a particular ...

Medical research

Overactive immune response blocks itself

As part of the innate immune system natural killer cells (NK cells) play an important role in immune responses. For a long time they have been known as the first line of defense in the fight against infectious diseases. Therefore, ...

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