In one of the first studies addressing the role of sex hormones' impact on stem cells in the gut, scientists outline new insights showing how a steroidal sex hormone, that is structurally and functionally similar to human ...
Jul 9, 2020
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44
Deep within the lining of the human intestine lies the source of the organ's ability to renew itself and recover from damage: intestinal stem cells (ISCs), lodged in pockets of tissue called crypts, generate the cells that ...
Feb 20, 2020
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326
Benign intestinal tumors with mutations that delete or inactivate two particular tumor-suppressing genes develop more quickly towards cancerous forms, according to new research from the Crick.
Jan 6, 2020
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39
Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a Rutgers study.
Nov 25, 2019
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576
Researchers at the University of Helsinki have discovered how regenerative capacity of intestinal epithelium declines when we age. Targeting of an enzyme that inhibits stem cell maintaining signaling rejuvenates the regenerative ...
Jul 10, 2019
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160
Babies born prematurely often face intense medical challenges, including intestines that are underdeveloped or diseased. While an intestine transplant can benefit some patients, many babies are simply too small to endure ...
Jun 7, 2019
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The survival and fitness of multicellular organisms is tightly associated with their capacity to renew their tissues. This is particularly important for tissues that are permanently exposed to and challenged by the external ...
Jun 4, 2019
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422
Cells that line the intestinal tract are replaced every few days, a high rate of turnover that relies on a healthy population of intestinal stem cells. MIT and University of Tokyo biologists have now found that aging takes ...
Mar 28, 2019
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166
Researchers at Universitätsmedizin Berlin have discovered a protective mechanism which is used by the body to protect intestinal stem cells from turning cancerous. The body's innate immune system was found to play a pivotal ...
Feb 1, 2019
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152
The master regulators of gut stem cells, called intestinal myofibroblasts, have pumps that protect them, and thus the gut, from the toxic effects of a wide range of compounds, including the anticancer drug tamoxifen, according ...
Aug 24, 2018
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104
