Genetics

The surprising twist behind a rare neurological disorder

A fruit fly study, by an international group of researchers, has pinpointed how a genetic mutation causes one of the important molecular machines in our cells to malfunction. The findings provide a biological mechanism behind ...

Medical research

Esophagus organoid holds promise for cancer research

Researchers at the University of Szeged in Hungary have demonstrated for the first time that an esophagus organoid successfully duplicates a vital function of that organ. The study is published in the American Journal of ...

Medical research

Transporter imbalance implicated in schizophrenia

Alterations in the balance of two chloride ion transporters may be responsible for cognitive deficits in schizophrenia, according to a Northwestern Medicine study published in Science Advances.

Medical research

Protein twist and squeeze confers cancer drug resistance

In 1986, cellular biochemist Kazumitsu Ueda, currently at Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS), discovered that a protein called ABCB1 could transport multiple chemotherapeutics out of ...

Immunology

Transporter's role in gut barrier linked to intestinal dysfunction

The cotransporter NKCC1 moves sodium, potassium and chloride ions across the cell membrane of many cell types, including intestinal epithelial cells. Two patients with mutations in NKCC1 suffered from severe intestinal dysfunction ...

Medical research

New research sheds light 'gender gap' in cystic fibrosis

A minor hiccup in the sequence of a human gene can have devastating impacts on health. Such flaws cause cystic fibrosis (CF), a disease affecting the lungs and other vital organs, often leading to death by the age of 30.

Medical research

An 'unconventional' path to correcting cystic fibrosis

Researchers have identified an unconventional path that may correct the defect underlying cystic fibrosis, according to a report in the September 2nd issue of the journal Cell. This new treatment dramatically extends the ...

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