Neuroscience

Blunting pain's emotional component

Chronic pain involves more than just hurting. People suffering from pain often experience sadness, depression and lethargy. That's one reason opioids can be so addictive—they not only dampen the pain but also make people ...

Medical research

New clues point to relief for chronic itching

A common side effect of opioids is intense itching—a problem for some patients who need the drugs for pain relief and for others fighting addiction.

Medical research

Scientists take a big step toward building a better opioid

For the first time, scientists at the University of North Carolina School of Medicine and collaborators solved the crystal structure of the activated kappa opioid receptor bound to a morphine derivative. They then created ...

Neuroscience

Scientists identify novel compound to alleviate pain and itch

In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a possible drug candidate that suppresses pain and itch in animal models. Their new approach also reduces the potential ...

Neuroscience

Researchers uncover how kappa opioid receptors drive anxiety

University of North Carolina researchers uncovered a cellular mechanism by which kappa opioid receptors (KOR) drive anxiety. These proteins inhibit the release of the neurotransmitter glutamate in a part of the brain that ...

Other

Why menthol chills your mouth when it's not actually cold

Try putting an ice-cube in your mouth. The insides of your mouth and tongue instantly turn numb. Hold it in still and you will feel pain. Now try sucking on peppermint. The mint itself is at room temperature, but your mouth ...

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