Ruxolitinib, a drug that is already approved by the U.S. Food and Drug Administration (FDA) for treating certain cancers and skin conditions, is effective at inhibiting CaMKII, a protein kinase linked to cardiac arrhythmias.
Jun 21, 2023
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New research in the June 2023 issue of Journal of the National Comprehensive Cancer Network has found that when alectinib—a safe and effective small molecule kinase inhibitor used to treat some types of advanced lung cancer—was ...
Jun 12, 2023
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First-line ibrutinib (Imbruvica) plus venetoclax (Venclexta) led to high response and survival rates in patients with chronic lymphocytic leukemia (CLL) whether or not their cancer harbored high-risk genetic features typically ...
Jun 7, 2023
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In a multi-center phase 1 and 2 trial (BRUIN, NCT03740529), researchers from leading cancer centers across the globe, including the Medical College of Wisconsin (MCW) in Milwaukee, tested Bruton tyrosine kinase inhibitor ...
Jun 2, 2023
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Scientists at Duke-NUS Medical School, A*STAR's Genome Institute of Singapore (GIS), Singapore General Hospital (SGH) and their colleagues in Singapore have used artificial intelligence (AI) to accelerate the discovery of ...
Jun 1, 2023
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Brepocitinib is an oral drug that inhibits certain enzymes involved in inflammation—called tyrosine kinase 2 and Janus kinase 1—and is being tested for the treatment of several immunological diseases. A phase IIb randomized ...
May 17, 2023
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When it comes to cancer, developing resistance to therapy and metastasis, the ability to spread outside the organ of origin, are issues of major concern as they give cancer the upper hand.
May 17, 2023
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For centuries, scientists have tried to crack the mystery of a devastating ailment once called "the shaking palsy." But Parkinson's disease, which causes tremors, muscle stiffness and difficulty walking, remains the second ...
Apr 21, 2023
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Northwestern Medicine scientists have identified an enzyme which aids tumors in evading the immune system, findings that could provide future directions for tumor treatment, according to a study published in Nature Communications.
Apr 12, 2023
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A recent study from Texas Children's Hospital and Baylor College of Medicine has expanded the clinical spectrum of a new epileptic disorder called Intellectual Developmental Disorder with Macrocephaly, Seizures, and Speech ...
Mar 29, 2023
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