The outcomes of chronic myeloid leukemia (CML) have dramatically improved as the result of tyrosine kinase inhibitor (TKI) treatment. Use of a TKI regimen can lower the blood CML biomarker to levels imperceptible by current ...
Feb 5, 2016
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In a mouse model of allergic asthma, dasatinib—an enzyme inhibitor approved for the treatment of chronic myelogenous leukemia—reduced inflammation, enhanced airway repair, and improved lung mechanics.
Feb 1, 2016
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1
An international public-private research consortium has identified and validated a cellular role of a primary Parkinson's disease drug target, the LRRK2 kinase. This important finding, published in the online, open-access ...
Jan 28, 2016
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Non-small cell lung cancer (NSCLC) patients with common epidermal growth factor (EGFR) mutations and brain metastases showed improved progression-free survival (PFS) and response from the EGFR tyrosine kinase inhibitor (TKI) ...
Jan 25, 2016
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7
A group of protein kinases have been found to play an important role in embryo development and may even be a potential cancer drug target, says research led by Queen Mary University of London (QMUL) and the Francis Crick ...
Jan 7, 2016
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Patients with EGFR-activating mutations in advanced lung cancer seem to benefit more from afatinib than gefitinib as first-line treatment, researchers report at the first ESMO Asia 2015 Congress in Singapore.
Dec 21, 2015
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(HealthDay)—For patients with non-small-cell lung cancer, treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is associated with skin toxic effects, according to a research letter study ...
Dec 11, 2015
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In their recent study, Thomas Leonard and his group at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna have shown that the cellular activity of the enzyme ROCK is controlled ...
Dec 10, 2015
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Chronic lymphocytic leukemia (CLL) patients who stopped taking the kinase inhibitors (KIs), ibrutinib or idelalisib, had mostly favorable outcomes when they switched to the alternate therapy, according to a large multi-center ...
Dec 7, 2015
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Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have pinpointed five specific enzymes called protein kinases that play a role when prostate cancer spreads to bone. The discovery ...
Dec 2, 2015
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