Diseases, Conditions, Syndromes

Researchers review modern cases of leprosy

Leprosy has a history that has spanned centuries and societies across the globe. Yet, it continues to be a problem—even in the modern era. Sufferers from the chronic and infectious skin disease still face the social stigma ...

Diseases, Conditions, Syndromes

Leprosy declines in Morocco after implementation of preventive drug

Since 2012, the number of cases of leprosy in Morocco has declined by more than 16 percent per year. That change can be attributed to the implementation, beginning in 2012, of single dose rifampicin as a preventive to spread ...

Diseases, Conditions, Syndromes

More than half of Amazonian armadillos carry leprosy

The bacteria that causes leprosy, a chronic disease that can lead to disfigurement and nerve damage, is known to be transmitted to humans from nine-banded armadillos. A new study in PLOS Neglected Tropical Diseases reports ...

Diseases, Conditions, Syndromes

Publication details IDRI's promising leprosy vaccine candidate

A publication in Nature Partner Journals (npj) Vaccines indicates that post-exposure prophylaxis with LepVax, IDRI's leprosy vaccine candidate, not only appears safe but, unlike BCG (a tuberculosis vaccine that provides some ...

Diseases, Conditions, Syndromes

Researchers characterize unusual blood clots in leprosy patients

For years, doctors have observed that some patients with leprosy develop unusual blood clots which can lead to stroke or heart attack. Now, researchers reporting in PLOS Neglected Tropical Diseases have for the first time ...

Diseases, Conditions, Syndromes

Leprosy's drug resistance and origin revealed by genome analysis

Leprosy is an infectious disease with gruesome symptoms. It damages the skin, peripheral nerves, the upper respiratory tract, and the eyes. Despite being curable with multidrug therapy, leprosy still persists in many developing ...

Diseases, Conditions, Syndromes

Promising new leprosy vaccine moves into human trials

Today marks a significant step forward in the prevention and treatment of leprosy as the Infectious Disease Research Institute (IDRI) and American Leprosy Missions announce the start of a Phase 1 clinical trial in humans ...

Immunology

Leprosy turns the immune system against itself, study finds

Leprosy hijacks our immune system, turning an important repair mechanism into one that causes potentially irreparable damage to our nerve cells, according to new research that uses zebrafish to study the disease. As such, ...

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Leprosy

Leprosy or Hansen's disease (HD) is a chronic disease caused by the bacteria Mycobacterium leprae and Mycobacterium lepromatosis. Named after physician Gerhard Armauer Hansen, leprosy is primarily a granulomatous disease of the peripheral nerves and mucosa of the upper respiratory tract; skin lesions are the primary external sign. Left untreated, leprosy can be progressive, causing permanent damage to the skin, nerves, limbs and eyes. Contrary to folklore, leprosy does not cause body parts to fall off, although they can become numb or diseased as a result of secondary infections; these occur as a result of the body's defences being compromised by the primary disease. Secondary infections, in turn, can result in tissue loss causing fingers and toes to become shortened and deformed, as cartilage is absorbed into the body.

Although the mode of transmission of Hansen's disease remains uncertain, most investigators think that M. leprae is usually spread from person to person in respiratory droplets. Studies have shown that leprosy can be transmitted to humans by armadillos. Leprosy is now known to be neither sexually transmitted nor highly infectious after treatment. Approximately 95% of people are naturally immune and sufferers are no longer infectious after as little as 2 weeks of treatment.

The minimum incubation period reported is as short as a few weeks, based on the very occasional occurrence of leprosy among young infants. The maximum incubation period reported is as long as 30 years, or over, as observed among war veterans known to have been exposed for short periods in endemic areas but otherwise living in non-endemic areas. It is generally agreed that the average incubation period is between three and five years.

Leprosy has affected humanity for over 4,000 years, and was well-recognized in the civilizations of ancient China, Egypt, and India. In 1995, the World Health Organization (WHO) estimated that between 2 and 3 million people were permanently disabled because of leprosy at that time. In the past 20 years, 15 million people worldwide have been cured of leprosy. Although the forced quarantine or segregation of patients is unnecessary in places where adequate treatments are available, many leper colonies still remain around the world in countries such as India (where there are still more than 1,000 leper colonies), China, Romania, Egypt, Nepal, Somalia, Liberia, Vietnam, and Japan. Leprosy was once believed to be highly contagious and was treated with mercury — all of which applied to syphilis, which was first described in 1530. It is now thought that many early cases of leprosy could have been syphilis[clarification needed].

The age-old social stigma associated with the advanced form of leprosy lingers in many areas, and remains a major obstacle to self-reporting and early treatment. Effective treatment for leprosy appeared in the late 1930s with the introduction of dapsone and its derivatives. Leprosy bacilli resistant to dapsone soon evolved and, due to overuse of dapsone, became widespread. It was not until the introduction of multidrug therapy (MDT) in the early 1980s that the disease could be diagnosed and treated successfully within the community.

MDT for multibacillary leprosy consists of rifampicin, dapsone, and clofazimine taken over 12 months. Dosages adjusted appropriately for children and adults are available in all primary health centres in the form of blister packages. Single dose MDT for single lesion leprosy consists of rifampicin, ofloxacin, and minocycline. The move toward single-dose treatment strategies has reduced the prevalence of disease in some regions, since prevalence is dependent on duration of treatment.

World Leprosy Day was created to draw awareness to leprosy and its sufferers.

This text uses material from Wikipedia, licensed under CC BY-SA