Oncology & Cancer

Molecular mechanisms reveal how to make the most of methotrexate

St. Jude Children's Research Hospital scientists have identified factors that influence how children with acute lymphoblastic leukemia (ALL) respond to methotrexate. High-dose methotrexate is a part of modern curative therapy ...

Oncology & Cancer

'BAH-code' reader senses gene-silencing tag in cells

University of North Carolina Lineberger Comprehensive Cancer Center researchers have identified a new and evolutionarily conserved pathway responsible for "closing down" gene activity in the mammalian cell. The finding is ...

Medical research

New therapeutic approach against leukemia

Leukemia frequently originates from the so-called leukemic stem cell, which resides in a tumor promoting and protecting niche within the bone marrow. Scientists from the Max Planck Institute of Biochemistry in Martinsried, ...

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