For patients with acute lymphoblastic leukemia with resistance to C19 CAR T-cell therapy, resistance mechanisms that can be detected prior to treatment have been identified, according to a study presented at the annual meeting ...
Apr 12, 2022
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Acute lymphoblastic leukemia (ALL) cells from patients whose cancers did not respond to CD19-targeted CAR T therapy had gene regulation signatures that could potentially facilitate treatment resistance, according to results ...
Apr 12, 2022
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New research has begun to unravel the mystery of why a particular form of leukemia in infants has defied efforts to improve outcomes, despite significant improvements in treating older children. Scientists from the Wellcome ...
Mar 14, 2022
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Some genetic mutations linked to leukemia are less than useful guides to making treatment decisions for patients. A new study from the University of Wisconsin–Madison suggests a group of clinical signs that can be paired ...
Feb 22, 2022
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A woman with HIV who received a cord blood stem cell transplant to treat acute myeloid leukemia has had no detectable levels of HIV for 14 months despite cessation of antiretroviral therapy (ART), according to a presentation ...
Feb 15, 2022
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An immunotherapy harnessing the immune system's "natural killer" cells has proven effective in treating acute myeloid leukemia (AML) in some adults whose cancers return. Now, researchers at Washington University School of ...
Dec 14, 2021
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Scientists at St. Jude Children's Research Hospital have a new understanding of how a group of well-known fusion oncoproteins causes leukemia. The findings show the importance of liquid-liquid phase separation (LLPS), a process ...
Dec 13, 2021
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Acute myeloid leukemia (AML) is the second most common leukemia diagnosed in children. It is hard to treat and can be fatal in some cases. While there have been some recent successes with genetically targeted therapies for ...
Nov 5, 2021
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In some children with acute myeloid leukemia, cancer cells have as many DNA changes as healthy blood stem cells. Researchers were surprised to find these children have a poorer chance of survival compared with children whose ...
Aug 6, 2021
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Removing a protein that is often overexpressed in a rare and aggressive subtype of leukemia can help to slow the cancer's development and significantly increase the likelihood of survival, according to a study in mice led ...
Jul 29, 2021
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