Genetics

Epigenetic factors linked to obesity-related disease

Obesity has been linked to "letter" changes at many different sites in the genome, yet these differences do not fully explain the variation in people's body mass index (BMI) or why some overweight people develop health complications ...

Oncology & Cancer

Lipid metabolism is potential 'Achilles' heel' for cancer stem cells

Researchers have discovered a metabolic signature critical for the functioning of "cancer stem cells" that initiate tumor formation. The team also showed how to interfere with this metabolic mechanism in ovarian cancer, inhibiting ...

Overweight & Obesity

Study finds link between carbohydrate consumption and adropin

In research featured in the August edition of Obesity, Saint Louis University investigator Andrew Butler, Ph.D., and his team report that levels of the peptide hormone adropin vary based on carbohydrate consumption and appear ...

Medical research

Lung tumors hijack metabolic processes in the liver, study finds

University of California, Irvine scientists who study how circadian rhythms—our own body clocks—control liver function have discovered that cancerous lung tumors can hijack this process and profoundly alter metabolism.

Oncology & Cancer

Research points to a new treatment for pancreatic cancer

Researchers have shown how controlling cholesterol metabolism in pancreatic cancer cells reduces metastasis, pointing to a potential new treatment using drugs previously developed for atherosclerosis.

Overweight & Obesity

Dietary polyphenols don't provide much CV benefit in metabolic sx

(HealthDay)—Supplementation with polyphenols does not strongly protect against cardiovascular diseases among patients with metabolic syndrome (MetS), according to a review published online April 15 in Obesity Reviews.

Overweight & Obesity

PDE4 inhibition promising tx for metabolic disorders

(HealthDay)—Inhibition of phosphodiesterase-4 (PDE4), which hydrolyses cyclic adenosine monophosphate (cAMP), may be useful for treating metabolic disorders, according to research published in the May issue of Obesity Reviews.

Alzheimer's disease & dementia

Evidence of a lipid link in the inherited form of Alzheimer's disease

Australian researchers have found biochemical changes occurring in the blood, in the rare inherited form of Alzheimer's disease. Changes in these fat-like substances, may suggest a method to diagnose all forms of Alzheimer's ...

Medical research

How a mutated gene wreaks havoc on white matter

An inherited disease of myelin marked by slow, progressive neurological impairment is caused by mutations of a gene that controls lipid metabolism, a finding that may shed insight into mechanisms to control the course of ...

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