Failure of an enzyme to break down DNA spilling into the bloodstream as cells die may be a major driver of inflammation in lupus. This is the finding of a study in both mice and human patients led by researchers at NYU Langone ...
Jun 9, 2016
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Antibodies to native double-stranded DNA are present in the blood of healthy people, but their level is increased many times in patients with autoimmune diseases in which the human immune system becomes hyperactive and attacks ...
Jun 6, 2016
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Researchers at Beth Israel Deaconess Medical Center (BIDMC) have identified an enzyme that is significantly elevated in mouse models of systemic lupus erythematosus and in blood samples of patients with lupus. Published online ...
May 16, 2016
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(HealthDay)—Neither the American College of Rheumatology (ACR) nor the Systemic Lupus International Collaborating Clinics (SLICC) criteria distinguishes patients with subacute cutaneous lupus erythematosus (SCLE) with major ...
Apr 27, 2016
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Researchers at the Baylor Institute for Immunology Research have discovered that the neutrophils of systemic lupus erythematosus (SLE) patients release oxidized DNA from their mitochondria that can stimulate an unwanted immune ...
Apr 18, 2016
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A signaling molecule called interferon gamma could hold the key to understanding how harmful autoantibodies form in lupus patients. The finding could lead to new treatments for the chronic autoimmune disease, said researchers ...
Apr 12, 2016
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For years doctors have been advising patients with lupus not to get pregnant. It was assumed that the likelihood of pregnancy complications was too high in this population. However, ongoing work by researchers at Hospital ...
Nov 9, 2015
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A study at Hospital for Special Surgery (HSS) evaluating the Patient Reported Outcomes Measurement Information System (PROMIS) in patients with lupus finds that the questionnaire is valid in assessing subjective patient experience. ...
Nov 7, 2015
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Activating an enzyme that sounds an alarm for the body's innate immune system causes two lethal autoimmune diseases in mice, while inhibiting the same enzyme rescues them, UT Southwestern Medical Center researchers report.
Oct 27, 2015
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Scientists have calculated more precise measurements of heritability—the influence of underlying genes—in nine autoimmune diseases that begin in childhood. The research may strengthen researchers' abilities to better ...
Oct 9, 2015
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