A dysfunctional immune system significantly contributes to the development of cancer. Several therapeutic strategies to activate the immune system to target cancer cells have been approved to treat different types of cancer, ...
Apr 8, 2021
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A personalized tumor cell vaccine strategy targeting Myc oncogenes combined with checkpoint therapy creates an effective immune response that bypasses antigen selection and immune privilege, according to a pre-clinical study ...
Apr 2, 2021
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Some melanoma patients respond very well to immunotherapy, experiencing profound and durable tumor regression. A fraction of these patients will also develop autoimmunity against their normal melanocytes—the cells that ...
Mar 24, 2021
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There have been great advances in treating melanoma over the past five years, however, even with these treatments many patients quickly develop drug resistance and die from their disease. A new study from Boston University ...
Feb 1, 2021
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Four years after patients with melanoma were treated with a personalized cancer vaccine, the immune response kindled by the vaccine remains robust and effective in keeping cancer cells under control, researchers at Dana-Farber ...
Jan 21, 2021
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Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for ...
Jan 12, 2021
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In their move to circumvent the immune system, melanoma cells end up with a deficiency of the crucial nutrient tryptophan. Unlike healthy cells, these cancer cells can continue to synthesize proteins to survive, but this ...
Dec 17, 2020
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Researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) have identified a potential drug combination to treat uveal melanoma, a type of eye cancer. Lead author Amanda Truong, trainee in the McMahon ...
Dec 3, 2020
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A Vanderbilt cancer systems biology team has identified the enzymes that keep tumor cells growing in the presence of drug treatment, opening the door to stopping these cells dead in their tracks.
Oct 22, 2020
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Research led by Queen Mary University of London has revealed novel insights into the mechanisms employed by melanoma cells to form tumors at secondary sites around the body. The findings from the study may help to identify ...
Oct 20, 2020
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