Page 15 - News tagged with mesenchyme

Medical research

'Bad guy' fibrocytes could help rebuild damaged tissue

Could a blood cell type responsible for scarring and diseases such as pulmonary fibrosis be repurposed to help engineer healthy tissue?

May 9, 2019

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Medical research

Stem cells make more 'cargo' packets to carry cellular aging therapies

Johns Hopkins scientists report that adult cells reprogrammed to become primitive stem cells, called induced pluripotent stem cells (iPSCs), make tiny "cargo packets" able to deliver potentially restorative or repairing proteins, ...

May 7, 2019

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Oncology & Cancer

Scientists discover an interaction that helps cancers spread to bone

A Princeton-led team of researchers have discovered a factor that promotes the spread of cancers to bone, opening the way toward treatments that could mitigate cancer's ability to colonize bone. The study by Mark Esposito, ...

Apr 15, 2019

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Medical research

Human iPSC-derived MSCs from aged individuals acquire a rejuvenation signature

The use of primary mesenchymal stem cells (MSCs) is fraught with aging-related shortfalls such as limited expansion and early senescence. Human induced pluripotent stem cells (iPSCs) derived MSCs (iMSCs) comprise a useful, ...

Apr 11, 2019

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Medical research

Leukocytes use their nucleus as a ruler to choose path of least resistance

How do mobile cell types like leukocytes or metastatic cancer cells reach their place of action during immune surveillance or cancer dissemination, respectively? The research group around Michael Sixt at IST Austria has now ...

Apr 3, 2019

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Medical research

Rejuvenation of aging cells helps to cure osteoarthritis through gene therapy

Aging is a risk factor for the development of osteoarthritis (OA), a chronic disease characterized by degeneration of articular cartilage leading to pain and physical disability. Senescent mesenchymal stem cells (hMSCs) are ...

Mar 28, 2019

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Oncology & Cancer

ZEB1 throttles therapeutic target, protecting KRAS-mutant lung cancer

A cellular identity switch protects a cancer-promoting genetic pathway from targeted therapy, researchers at The University of Texas MD Anderson Cancer Center today reported in Science Translational Medicine.

Mar 13, 2019

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Medical research

New regulatory factor identified in bone formation

Researchers report the identification of a novel transcription factor that helps regulate the differentiation of mesenchymal stem cells (MSCs) into bone in mice. Bone cell differentiation is still poorly understood, and MSCs ...

Mar 11, 2019

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Oncology & Cancer

Protein loss promotes cell migration

The protein STK17A (serine threonine kinase 17A) appears to play roles in various cancer types. It can be oncogenic or tumor suppressive, depending on the cancer, but its role in colorectal cancer has not been established.

Mar 1, 2019

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