The popular painkiller ibuprofen may have more significant effects on the liver than previously thought, according to new research from the University of California, Davis. The study in laboratory mice also shows marked differences ...
Mar 11, 2020
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Scientists at the Laboratoire des Maladies Neurodégénératives (CNRS/CEA/Université Paris-Saclay) and the Neurocentre Magendie (INSERM/Université de Bordeaux) have just shown that a metabolic pathway plays a determining ...
Mar 3, 2020
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Serine racemase (SRR) is a multifunctional enzyme that carries out several different reactions in human cells, including the conversion of L-serine into pyruvate. Though already well characterized, a team of researchers led ...
Jan 29, 2020
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In a study by The Wistar Institute and collaborators, a rare, African-specific variant of the TP53 gene called P47S causes iron accumulation in macrophages and other cell types and is associated with poorer response to bacterial ...
Jan 24, 2020
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The size of the human brain increased profoundly during evolution. A certain gene that is only found in humans triggers brain stem cells to form a larger pool of stem cells. As a consequence, more neurons can arise, which ...
Jan 7, 2020
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Fatty liver, or hepatic steatosis, which develops when the body produces too much fat or doesn't metabolize fat efficiently enough, affects around 25% of the global population. Excess fat is stored in liver cells, where it ...
Dec 20, 2019
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New research may lead to improved methods to diagnose inflammatory bowel disease (IBD) in children. This could be especially beneficial for those experiencing malnutrition and impaired growth as a result of this condition, ...
Dec 13, 2019
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Colon cancer cells deficient in p53, one of the most important control proteins in cell growth, activate a particular metabolic pathway to adapt to the lack of oxygen and nutrients inside the tumor. Statins, which are often ...
Dec 12, 2019
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A new screening system developed by scientists at the UCLA Jonsson Comprehensive Cancer Center leverages redundancy in an important component of a cell—nucleotide metabolism—to help identify new drugs that specifically ...
Nov 18, 2019
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A compound developed by Johns Hopkins researchers that blocks glutamine metabolism can slow tumor growth, alter the tumor microenvironment and promote the production of durable and highly active anti-tumor T cells.
Nov 8, 2019
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